Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures.

Abstract

Weightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory levels. However, the mechanisms involved in vascular dysfunction and remodeling are not sufficiently studied in the context of weightlessness and its analogs including models of physical inactivity. Here, we summarize vascular and microvascular changes induced by space flight and observed in models of microgravity and physical inactivity and review the effects of prophylactic strategies (i.e., countermeasures) on vascular and microvascular function. We discuss physical (e.g., exercise, vibration, lower body negative pressure, and artificial gravity) and nutritional/pharmacological (e.g., caloric restriction, resveratrol, and other vegetal extracts) countermeasures. Currently, exercise countermeasure appears to be the most effective to protect vascular function. Although pharmacological countermeasures are not currently considered to fight vascular changes due to microgravity, nutritional countermeasures are very promising. Dietary supplements/natural health products, especially plant extracts, should be extensively studied. The best prophylactic strategy is likely a combination of countermeasures that are effective not only at the cardiovascular level but also for the organism as a whole, but this strategy remains to be determined.

Author: Navasiolava N, Yuan M, Murphy R, Robin A, Coupe M, Wang L, Alameddine A, Gauquelin-Koch G, Gharib C, Li Y, Custaud MA

Organization: Clinical Research Center, CHU d'Angers, Angers, France.

Year: 2020

GID: 5208

Created on: 19.10.2020

The verdict of our customers: Excellent

4.7/5

4.7 out of 5 stars based on 868 reviews

TÜV certified

We are a TÜV certified manufacturer for medical products.

Made in Germany

Development and manufacturing in Germany.

Proven quality

10 years service guarantee & more than 35 years experience in the company group.

Research studies

over 2000 scientific publications about our products.

Active worldwide

Internationally active with our distribution partners.

Start typing to see posts you are looking for.