For the first time, raloxifene or alendronate was administered to rats immediately after ovariectomy for 10 months and compared with es...
Raloxifene, tamoxifen, nafoxidine, or estrogen effects on reproductive and nonreproductive tissues in ovariectomized rats
For the first time, four well-characterized compounds from four distinct chemical classes were directly compared for efficacy and poten...
Effects of wortmannin analogs on bone in vitro and in vivo
The possible importance of phosphatidylinositol (PI) 3-kinase activity in bone resorption activity in vitro and in vivo were evaluated ...
Regional analysis of bone mineral density in the distal femur and proximal tibia using peripheral quantitative computed tomography in the rat In vivo
The use of peripheral quantitative computed tomography (pQCT) was investigated for the measurement of volumetric bone mineral density (...
Genetic variability in adult bone density among inbred strains of mice
More than 70% of the variability in human bone density has been attributed to genetic factors as a result of studies with twins, osteop...
Raloxifene preserves bone strength and bone mass in ovariectomized rats
We investigated the effects of raloxifene, a nonsteroidal benzothiophene, on bone strength in ovariectomized rats and compared them wit...
Comparative x-ray densitometry of bones from ovariectomized rats
Comparative analysis of dual energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) with phantoms and rat bones s...
Assessing bone quantity by pQCT
We have tested the ability of the XCT960A to detect bone loss in OVX-rats, as well as bone gain in the proximal tibial metaphysis of he...
Effect of treatment for 3 months with human parathyroid hormone 1-34 peptide in ovariectomized cynomolgus monkeys (Macaca fascicularis)
Clinical data suggest that PTH may increase cancellous bone mass at the expense of cortical bone in human beings. In this study, the ef...
Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density
Human growth hormone (hGH) and insulin-like growth factor I (IGF-I) both stimulate bone formation and have been proposed as therapeutic...