Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model
Aromatization of androgens into estrogens may be important for maintenance of the male skeleton. To address this hypothesis, we evaluat...
Spontaneous fracture (sfx): a mouse genetic model of defective peripubertal bone formation
A new mouse model of stage-specific bone growth failure and fracture has been recovered as an autosomal recessive mutation, designated ...
How cancellous and cortical bones adapt to loading and growth hormone
There is great interest in the relationships between growth hormone (GH), muscle loading and bone, in part, because GH increases muscle...
PTH and interactions with bisphosphonates
We report that a therapeutic dose of the antiresorptive bisphosphonate alendronate administered to skeletally mature rats for the durat...
Mineral density and bone strength are dissociated in long bones of rat osteopetrotic mutations
Bone mineral density (BMD) and mechanical strength generally show strong positive correlations. However, osteopetrosis is a metabolic b...
Effects of dietary calcium depletion and repletion on dynamic determinants of tibial bone volume in two inbred strains of mice
As an adjunct to our efforts to identify the genes that determine peak bone density, we examined phenotypic differences between two inb...
Bone resorption induced by 1 alpha,25 dihydroxyvitamin D(3) in vivo is not altered by inactivation of the plasminogen activator inhibitor 1
One of the proteolytic systems produced by bone cells is the plasminogen activator/plasmin pathway, which involves the two plasminogen ...
Anabolic effect of aminoterminally truncated fibroblast growth factor 4 (FGF4) on bone
Fibroblast growth factor 4 (FGF4), a member of the FGF family, plays several important roles in bone development during embryogenesis. ...
Parathyroid hormone and growth hormone have additive or synergetic effect when used as intervention treatment in ovariectomized rats with established osteopenia
The severely osteoporotic human skeleton is characterized by thin cortices and a very fragile cancellous framework. To increase the bio...