The mouse is increasingly being used as an animal model for the study of skeletal phenotypes in humans, mainly because of the ease of g...
Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
Serum insulin-like growth factor-1 (IGF-1) and femoral bone mineral density (BMD) differ between two inbred strains of mice, C3H/HeJ (C...
Some vegetables (commonly consumed by humans) efficiently modulate bone metabolism
We have hypothesized that some vegetables which are part of the regular human diet may contain modulators of bone metabolism. To mimic ...
Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice
In this study we used a mouse model system to compare the in vivo effects of parathyroid hormone(1-34) with that of PTH(1-31) or PTH(2...
Effects of separate and combined therapy with growth hormone and parathyroid hormone on lumbar vertebral bone in aged ovariectomized osteopenic rats
Previous studies have demonstrated that growth hormone (GH) has a marked anabolic effect on cortical bone, and parathyroid hormone (PTH...
Long-term effects of aging and orchidectomy on bone and body composition in rapidly growing male rats
The purpose of this study was to assess the long-term effects of aging and sex hormone deficiency on skeletal metabolism and body compo...
Analysis of biomechanical effects on bone and on the muscle-bone interactions in small animal models
Animal models are suitable to study many aspects of bone structure and strength. This article reviews some general principles of curren...
Postnatal and pubertal skeletal changes contribute predominantly to the differences in peak bone density between C3H/HeJ and C57BL/6J mice
Previous studies have shown that 60-70% of variance in peak bone density is determined genetically. The higher the peak bone density, t...
Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice
To test the hypothesis that factors associated with bone strength (i.e., volumetric bone mineral density , geometry, and microstructure...
Atherogenic high-fat diet reduces bone mineralization in mice
The epidemiological correlation between osteoporosis and cardiovascular disease is independent of age, but the basis for this correlati...