Identification of bone selective vitamin D analogues would provide an interesting substance class for the treatment of osteoporosis. Th...
Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone
Departing from the premise that it is the large-amplitude signals inherent to intense functional activity that define bone morphology, ...
A time course of bone response to jump exercise in C57BL/6J mice
Exercise, by way of mechanical loading, provides a physiological stimulus to which bone tissue adapts by increased bone formation. The ...
Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo
In vivo studies have shown T cells to be central to the mechanism by which estrogen deficiency induces bone loss, but the mechanism inv...
Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats
The purpose of this study was to examine site- and compartment-specific changes in bone induced by hindlimb unloading (HU) in the matur...
Repeated in vivo determinations of bone mineral density during parathyroid hormone treatment in ovariectomized mice
The recent development of different genetically modified mice with potentially interesting bone phenotypes has increased the demand for...
Effects of cerivastatin and parathyroid hormone on the lumbar vertebra of aging male Sprague-Dawley rats
Both men and women lose bone at a late age (aging bone loss). The aim of this study was to determine whether cerivastatin and parathyro...
Bone mineral content and density in the humerus of adult myostatin-deficient mice
Myostatin (GDF-8), a member of the transforming growth factor-b superfamily of secreted growth and differentiation factors, is a negati...
Effects of high-frequency, low-magnitude mechanical stimulus on bone healing
Recent studies have shown osteogenic effects of high-frequency mechanical stimuli. The purpose of this study was whether externally app...
Influence of a low calcium and phosphorus diet on the anabolic effect of human parathyroid hormone (1-38) in female rats
Parathyroid hormone (PTH) or synthetic N-terminal PTH fragments administered intermittently have been established as anabolic agents in...