pQCT provides better prediction of canine femur breaking load than does DXA
Our study was designed to examine the validity of dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomograph...
Estrogen and bone–a reproductive and locomotive perspective
The primary function of the skeleton is locomotion, and the primary function of estrogen is reproduction. When the skeleton is consider...
Differential effects on bone of estrogen receptor alpha and androgen receptor activation in orchidectomized adult male mice
Androgens may regulate the male skeleton either directly by stimulation of the androgen receptor (AR) or indirectly by aromatization of...
Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation
Large amounts of calcium are transferred to offspring by milk. This demand results in negative calcium balance in lactating mothers and...
A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice
Although the role of estradiol in maintaining bone mass is well established, the relative contributions of the estradiol receptors ERal...
Age-related changes in bone mineral content and density in intact male F344 rats
This study was undertaken to determine whether age-related bone loss occurs in intact male F344 rats. Bone loss was assessed in male F3...
Ibandronate treatment decreases the effects of tumor-associated lesions on bone density and strength in the rat
Bisphosphonate treatment is beneficial against symptoms of metastatic bone disease, although less is known about the effect of preventa...
Evidence that sensitivity to growth hormone (GH) is growth period and tissue type dependent: studies in GH-deficient lit/lit mice
We previously found that the magnitude of skeletal deficits caused by GH deficiency varied during different growth periods. To test the...
Effects of SP500263, a novel selective estrogen receptor modulator, on bone, uterus, and serum cholesterol in the ovariectomized rat
We describe here the activity of a novel selective estrogen receptor modulator, SP500263. When given to adult ovariectomized (OVX) rats...
