Pure estrogenic effect of benzophenone-2 (BP2) but not of bisphenol A (BPA) and dibutylphtalate (DBP) in uterus, vagina and bone
Contradictory results whether the endocrine disrupters (ED) benzophenone-2 (BP2), bisphenol A (BPA) and dibutylphtalate (DBP) exert est...
Everolimus suppresses cancellous bone loss, bone resorption, and cathepsin K expression by osteoclasts
The proliferation inhibitor of the macrolide class, everolimus, is a drug shown to be effective in the prevention of organ transplant r...
The deficiency of immunoregulatory receptor PD-1 causes mild osteopetrosis
Recently, the involvement of immune responses in metabolic bone disease and/or local bone destruction has received much attention. Cyto...
Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet
In this study, we examined changes in bone parameters and bone strength in rats fed low-Mg diets (experiment 1) and the effects of vita...
Insulin receptor substrate-1 is required for bone anabolic function of parathyroid hormone in mice
Bone anabolic action of PTH has been suggested to be mediated by induction of IGF-I in osteoblasts; however, little is known about the ...
Retinoid-induced bone thinning is caused by subperiosteal osteoclast activity in adult rodents
Excess of Vitamin A (retinol) and related compounds (retinoids) induces bone fragility and is associated with increased hip fracture in...
Response of the osteocyte syncytium adjacent to and distant from linear microcracks during adaptation to cyclic fatigue loading
Cyclic loading induces fatigue in bone and initiates a complex, functionally adaptive response. We investigated the effect of a single ...
Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats
To evaluate the biological effects of vitamin K2 (menatetrenone, MK-4) on ovariectomy (OVX)-induced bone loss, we have examined histolo...
Effects of grape seed proanthocyanidins extract on rat mandibular condyle
We investigated the effects of grape seed proanthocyanidins extract (GSPE) on bone formation by examining total and cortical bone mass,...
Belamcanda chinensis and the thereof purified tectorigenin have selective estrogen receptor modulator activities
Belamcanda chinensis (BC) belongs to the family of iridaceae and the isoflavone tectorigenin has been isolated from the rhizome of this...