Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss
INTRODUCTION: Estrogen deficiency results in trabecular bone loss, associated with T-cell proliferation in the bone marrow. Insulin-lik...
Estrogen and androgen play distinct roles in bone turnover in male mice before and after reaching sexual maturity
Aromatase is the sole enzyme which converts androgen into estrogen. We have reported that aromatase-knockout (ArKO) mice showed bone lo...
Different molecular mechanisms underlie ethanol-induced bone loss in cycling and pregnant rats
Chronic ethanol (EtOH) consumption can result in osteopenia. In the current study, we examined the modulation of EtOH-induced bone loss...
COX-2 is necessary for venous ligation-mediated bone adaptation in mice
In osteoblasts, cyclooxygenase 2 (COX-2) is the major isozyme responsible for production of prostaglandins. Prostaglandins are local me...
Problems in quantifying bone response to exercise in horses: a review
Detecting changes in bone during growth, training, rest from competition (spelling), and disease in horses requires imaging techniques ...
Raloxifene and vitamin K2 combine to improve the femoral neck strength of ovariectomized rats
We evaluated the skeletal effects of two osteoporosis therapies in an ovariectomized rat model, raloxifene and vitamin K2, as well as t...
Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice
The objective of this study was to evaluate the influence of heterozygous inactivation of one allele of the type II collagen gene (Col2...
Osteopenia and impaired fracture healing in aged EP4 receptor knockout mice
The EP4 receptor, one of the subtypes of the prostaglandin E2 (PGE2) receptor, plays a critical role in the anabolic effects of PGE2 on...
Beta-tricalcium phosphate (beta-TCP) graft combined with bone marrow stromal cells (MSCs) for posterolateral spine fusion
Macaque lumber posterolateral spine fusion (PLF) was performed by using beta-TCP graft combined with bone marrow derived stromal cells ...
Effects of pleiotrophin (PTN) over-expression on mouse long bone development, fracture healing and bone repair
Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The pre...