Pre-Clinical Studies Archives | Page 18 of 40 | Novotec Medical & Stratec Medizintechnik

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20 Jan 2025

20. January 2025

Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross

Strain-dependent differences in bone adaptive responses to loading among inbred mouse strains suggest that genetic background contribut...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse

Inflammation is a complex cellular and humoral response against trauma and infection, and its presence leads to destruction of tissue i...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific

Biglycan (bgn) is a small leucine-rich proteoglycan (SLRP) enriched in the extracellular matrix of skeletal tissues. While bgn is known...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Three-point bending of rat femur in the mediolateral direction: introduction and validation of a novel biomechanical testing protocol

Mediolateral three-point bending of the rat midfemur was developed to enable the assessment of the mechanical competence of the ellipti...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

The effects of first gestation and lactation on bone metabolism in dairy goats and milk sheep

The goal of the present study was to compare mobilization rate of calcium (Ca) from bone in pregnant and lactating goats and sheep. Blo...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength

Risk factors for osteoporotic hip fracture include reduced bone mineral density and poor structure of the femoral neck, both of which a...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition

We identified quantitative trait loci (QTL) that determined the genetic variance in serum IGF-I through genome-wide scanning of mice de...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats

A new SERM, CHF 4227.01, given to 6-month-old female rats immediately after ovariectomy, preserved bone mass and bone microarchitecture...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

ER alpha acts either through classical (ERE-mediated) or nonclassical (non-ERE) pathways. The generation of mice carrying a mutation th...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application

FR167356, a novel inhibitor of vacuolar ATPase, has high potency against osteoclast V-ATPase and low potency against lysosomal V-ATPase...

Identification of genetic loci that regulate bone adaptive response to mechanical loading in C57BL/6J and C3H/HeJ mice intercross

New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse

The mechanical phenotype of biglycan-deficient mice is bone- and gender-specific

Three-point bending of rat femur in the mediolateral direction: introduction and validation of a novel biomechanical testing protocol

The effects of first gestation and lactation on bone metabolism in dairy goats and milk sheep

Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength

Congenic mice provide in vivo evidence for a genetic locus that modulates serum insulin-like growth factor-I and bone acquisition

A new selective estrogen receptor modulator, CHF 4227.01, preserves bone mass and microarchitecture in ovariectomized rats

Skeletal effects of estrogen are mediated by opposing actions of classical and nonclassical estrogen receptor pathways

A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application

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