Pre-Clinical Studies Archives | Page 17 of 40 | Novotec Medical & Stratec Medizintechnik

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20 Jan 2025

20. January 2025

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development

Mutations in filamin B (FLNB), a gene encoding a cytoplasmic actin-binding protein, have been found in human skeletal disorders, includ...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Effects of loss of classical estrogen response element signaling on bone in male mice

The role of estrogen signaling in the male skeleton via estrogen receptor (ER)-alpha is now well established. ERalpha can elicit respon...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats

Recent evidence has demonstrated that long-term estrogen deprivation using aromatase inhibitor therapy in postmenopausal women with bre...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading

Estrogen and exercise influence cortical bone formation. Both affect bone during growth, but with complex interactions. We hypothesized...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo

Pregnancy-associated plasma protein (PAPP)-A, a protease for IGF binding protein (IGFBP)-2, -4, and -5, may enhance IGF action by incre...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Effect of a single botulinum toxin injection on bone development in growing rabbits

Intramuscular injections with botulinum toxin A (BTX-A) lead to a rapid decrease in muscle mass and force, but the effect of this drug ...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone

Recent experimental data suggest that the anabolic response of bone to changes in physical activity and mechanical loading may vary amo...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats

This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally matu...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice

It has been hypothesized that activation of peroxisome-proliferator-activated receptor-gamma (PPARgamma) by thiazolidinedione drugs can...

t2023est22nut0ss5zer

20 Jan 2025

20. January 2025

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

Increased expression of several osteoblastic proteases and MEPE (a bone matrix protein) occurs in X-linked hypophosphatemic rickets (hy...

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development

Effects of loss of classical estrogen response element signaling on bone in male mice

A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats

Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading

Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo

Effect of a single botulinum toxin injection on bone development in growing rabbits

Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone

Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats

Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice

Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin

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