Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development
Mutations in filamin B (FLNB), a gene encoding a cytoplasmic actin-binding protein, have been found in human skeletal disorders, includ...
Effects of loss of classical estrogen response element signaling on bone in male mice
The role of estrogen signaling in the male skeleton via estrogen receptor (ER)-alpha is now well established. ERalpha can elicit respon...
A single intravenous administration of zoledronic acid prevents the bone loss and mechanical compromise induced by aromatase inhibition in rats
Recent evidence has demonstrated that long-term estrogen deprivation using aromatase inhibitor therapy in postmenopausal women with bre...
Low-dose estrogen treatment suppresses periosteal bone formation in response to mechanical loading
Estrogen and exercise influence cortical bone formation. Both affect bone during growth, but with complex interactions. We hypothesized...
Pregnancy-associated plasma protein-A increases osteoblast proliferation in vitro and bone formation in vivo
Pregnancy-associated plasma protein (PAPP)-A, a protease for IGF binding protein (IGFBP)-2, -4, and -5, may enhance IGF action by incre...
Effect of a single botulinum toxin injection on bone development in growing rabbits
Intramuscular injections with botulinum toxin A (BTX-A) lead to a rapid decrease in muscle mass and force, but the effect of this drug ...
Increased osteogenic response to exercise in metaphyseal versus diaphyseal cortical bone
Recent experimental data suggest that the anabolic response of bone to changes in physical activity and mechanical loading may vary amo...
Differential bone and muscle recovery following hindlimb unloading in skeletally mature male rats
This study was designed to track the recovery of bone and muscle properties after 28 days of hindlimb unloading (HU) in skeletally matu...
Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice
It has been hypothesized that activation of peroxisome-proliferator-activated receptor-gamma (PPARgamma) by thiazolidinedione drugs can...
Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin
Increased expression of several osteoblastic proteases and MEPE (a bone matrix protein) occurs in X-linked hypophosphatemic rickets (hy...