Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene
COX-2 is a key enzyme involved in the response of bone to loading. However, using mice with a null mutation of the COX-2 gene, we found...
Chromosome 13 locus, Pbd2, regulates bone density in mice
Bone density is inherited as a complex polygenic trait. Previously, we identified two quantitative trait loci (QTLs) specifying the pea...
The bone-protective effect of the phytoestrogen genistein is mediated via ER alpha-dependent mechanisms and strongly enhanced by physical activity
Reduced estrogen levels occurring during menopause in women are accompanied by a variety of disorders, e.g. hot flushes, depressions, o...
Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: a preliminary study in rabbit mandibles
AIM: To examine the effectiveness of administering recombinant human bone morphogenetic protein-2 (rhBMP-2) in distraction osteogenesis...
Detecting novel bone density and bone size quantitative trait loci using a cross of MRL/MpJ and CAST/EiJ inbred mice
Most previous studies to identify loci involved in bone mineral density (BMD) regulation have used inbred strains with high and low BMD...
Increase of bone volume by a nanosecond pulsed laser irradiation is caused by a decreased osteoclast number and an activated osteoblasts
The biostimulatory effects of laser irradiation focus not only in the field of soft tissue but also bone formation. Studies have shown ...
1Alpha,25-dihydroxy-2beta(3-hydroxypropoxy)vitamin D3 (ED-71) suppressed callus remodeling but did not interfere with fracture healing in rat femora
INTRODUCTION: Because osteoporotic patients are prone to fractures, it must be considered whether or not patients undergoing drug thera...
Allogenic peripheral blood derived mesenchymal stem cells (MSCs) enhance bone regeneration in rabbit ulna critical-sized bone defect model
Mesenchymal stem cells (MSCs) were demonstrated to exist within peripheral blood (PB) of several mammalian species including human, gui...
Exercise-induced changes in the cortical bone of growing mice are bone- and gender-specific
Fracture risk and mechanical competence of bone are functions of bone mass and tissue quality, which in turn are dependent on the bone'...