Impact of androgens, growth hormone, and IGF-I on bone and muscle in male mice during puberty
The interaction between androgens and GH/IGF-I was studied in male GHR gene disrupted or GHRKO and WT mice during puberty. Androgens st...
Cholesterol-sensing receptors, liver X receptor alpha and beta, have novel and distinct roles in osteoclast differentiation and activation
The liver X receptor (alpha,beta) is responsible for regulating cholesterol homeostasis in cells. However, our studies using the LXRalp...
Femur mechanical properties in the F2 progeny of an NZB/B1NJ x RF/J cross are regulated predominantly by genetic loci that regulate bone geometry
Genetic analysis of an NZB/B1NJ x RF/J cross has identified QTLs for femur mechanical, geometric, and densitometric phenotypes. Most me...
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
Wnt/beta-catenin signaling has been proven to play a central role in bone biology. Unexpectedly, the Wnt antagonist Dkk2 is required fo...
Effects of cyclic versus daily hPTH(1-34) regimens on bone strength in association with BMD, biochemical markers, and bone structure in mice
We developed a cyclic PTH regimen with repeated cycles of 1-week on and off daily PTH injection and explored its effects on bone streng...
Multiple genetic loci from CAST/EiJ chromosome 1 affect vBMD either positively or negatively in a C57BL/6J background
Skeletal phenotype analyses of 10 B6.CAST-1 congenic sublines of mice have revealed evidence for the presence of three closely linked Q...
Type XIII collagen strongly affects bone formation in transgenic mice
To characterize the function of type XIII collagen, a transmembrane protein occurring at cell adhesion sites, we generated transgenic m...
Identification of novel genetic loci for bone size and mechanosensitivity in an ENU mutant exhibiting decreased bone size
Using a dominant ENU mutagenesis screen in C57BL/6J (B6) mice to reveal gene function, we identified a mutant, 917M, with a reduced bon...
Growth hormone injections improve bone quality in a mouse model of osteogenesis imperfecta
Systemic growth hormone injections increased spine and femur length in a mouse model of OI. Femur BMC, cross-sectional area, and BMD we...
Bone adaptation to a mechanical loading program significantly increases skeletal fatigue resistance
Using a mechanical loading program to induce bone adaptation, we found that small (100-fold. This indicates that a moderate exercise pr...