Genetic regulation of femoral bone mineral density: complexity of sex effect in chromosome 1 revealed by congenic sublines of mice
The findings that sex-specific effects on femoral structure and peak bone mineral density (BMD) are linked to quantitative trait loci (...
Effects of estradiol-17beta, testosterone and a black cohosh preparation on bone and prostate in orchidectomized rats
Estradiol (E2) and testosterone (T) effectively prevent orchidectomy (orx) induced osteoporosis. T, however, stimulates prostate prolif...
Age-change of bone mineral density in the distal radius of chimpanzees and japanese macaques
Using peripheral quantitative computed tomography (pQCT), we evaluated and analyzed age-related changes in bone mineral density and oth...
The effects of combination of alendronate and human parathyroid hormone(1-34) on bone strength are synergistic in the lumbar vertebra and additive in the femur of C57BL/6J mice
A cyclic PTH regimen is as effective as a daily regimen on bone density gain in humans and in improving bone quality in mice. Our previ...
A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing
CP-533,536, a newly discovered, non-prostanoid EP2 receptor-selective PGE2 agonist, stimulates local bone formation and enhances fractu...
Glucocorticoid treatment of ovariectomized sheep affects mineral density, structure, and mechanical properties of cancellous bone
Thus far, orthopedic research lacks a suitable animal model of osteoporosis. In OVX sheep, 6 months of steroid exposure reduced bone de...
Quantitative trait loci for BMD and bone strength in an intercross between domestic and wildtype chickens
With chicken used as a model species, we used QTL analysis to examine the genetic contribution to bone traits. We report the identifica...
Treatment of skeletally mature ovariectomized rhesus monkeys with PTH(1-84) for 16 months increases bone formation and density and improves trabecular architecture and biomechanical properties at the lumbar spine
Histomorphometric studies of treatments for osteoporosis in humans are restricted to iliac crest biopsies. We studied the effects of PT...
Exercise when young provides lifelong benefits to bone structure and strength
Short-term exercise in growing rodents provided lifelong benefits to bone structure, strength, and fatigue resistance. Consequently, ex...
High dietary phosphate intake reduces bone strength in the growing rat skeleton
Nutrition influences peak bone mass development in early adulthood. The effect of high dietary phosphate intake on the growing skeleton...