A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo
Statins potently inhibit 3-hydroxy-3-methylglutaryl-coenzyme A reductase, blocking downstream biosynthesis of isoprenoid lipids and cau...
High impact exercise is more beneficial than dietary calcium for building bone strength in the growing rat skeleton
The benefits of impact exercise and dietary calcium on bone development are controversial. We used inbred rats under highly controlled ...
Effects of treatment with parathyroid hormone 1-84 on quantity and biomechanical properties of thoracic vertebral trabecular bone in ovariectomized rhesus monkeys
Osteoporosis is characterized by impaired bone quality leading to increased susceptibility to fracture, particularly of the thoracic sp...
Epistatic effects contribute to variation in BMD in Fischer 344 x Lewis F2 rats
To further delineate the factors underlying the complex genetic architecture of BMD in the rat model, a genome screen for epistatic int...
Genetic loci affecting bone structure and strength in inbred COP and DA rats
Previous studies have shown that the Copenhagen 2331 (COP) and Dark Agouti (DA) rats have significant differences in bone structure and...
Impact of pregnancy-associated plasma protein-a deletion on the adult murine skeleton
INTRODUCTION:
The metalloproteinase, pregnancy-associated plasma protein-A (PAPP-A) functions to enhance local insulin-like growth fac...
Knee loading accelerates bone healing in mice
Knee loading is an anabolic loading modality that applies lateral loads to the knee. This study shows that loads applied to the proxima...
Relationships between densitometric and morphological parameters as measured by peripheral computed tomography and the compressive behavior of lumbar vertebral bodies from macaques (Macaca fascicularis)
STUDY DESIGN: The measured maximum compressive force and stress of lumbar vertebral bodies from cynomolgus monkeys were compared with p...
Semaphorin 3B is a 1,25-Dihydroxyvitamin D3-induced gene in osteoblasts that promotes osteoclastogenesis and induces osteopenia in mice
The vitamin D endocrine system is important for skeletal homeostasis. 1,25-Dihydroxyvitamin D(3) impacts bone indirectly by promoting ...
Short-term changes in serum PINP predict long-term changes in trabecular bone in the rat ovariectomy model
Serum procollagen I N-terminal propeptide (PINP) is a sensitive bone formation marker in humans. We have developed a nonradioactive imm...