Bone anabolic effects of separate and combined therapy with growth hormone and parathyroid hormone on femoral neck in aged ovariectomized osteopenic rats
Previous studies have demonstrated that growth hormone (GH) has a marked anabolic effect on cortical bone and parathyroid hormone (PTH)...
Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation
Insulin-like growth factor I (IGF-I) is an important growth factor for bone, yet the mechanisms that mediate its anabolic activity in t...
An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement
The aim of this study was to evaluate the effects of different doses of androgen replacement, both on body composition and bone, in an ...
Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha
Estrogen deficiency induces bone loss by upregulating osteoclastogenesis by mechanisms not completely defined. We found that ovariectom...
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
Androgens may regulate the male skeleton directly through a stimulation of androgen receptors or indirectly through aromatization of an...
Defective bone formation and anabolic response to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase
Nitric oxide (NO) is a pleiotropic signaling molecule that is produced by bone cells constitutively and in response to diverse stimuli ...
Increase of intestinal calcium absorption and bone mineral density by heated algal ingredient (HAI) in rats
Active absorbable calcium (AAACa) produced by adding HAI (heated algal ingredient) to oyster shell calcium (AACa) is quite efficiently ...
Comparison of radiographic and pQCT analyses of healing rat tibial fractures
Fracture healing and callus formation have traditionally been evaluated by using X-ray radiography. Here we compared X-ray radiography ...
Bone mass changes of tibial and vertebral bones in young and adult rats with collagen-induced arthritis
To study the effect of arthritis on bone mass, bone mineral density (BMD) of cancellous and cortical bone in the tibial metaphysis and ...
Multiple cellular phenotypes in an insertional mutation in mouse affecting bone development
The 6093 line of transgenic mice exhibits altered bone development as a result of an insertional mutation by the transgene. Female tran...