Effects of increased muscle mass on bone in male mice overexpressing IGF-I in skeletal muscles
It has been hypothesized that increase in muscle mass increases the strain on bone resulting in increase in bone mass. The aim of the p...
Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption
The P2X7 nucleotide receptor is an ATP-gated ion channel expressed widely in cells of hematopoietic origin. Our purpose was to explore ...
Effect of protein-energy malnutrition in early life on the dimensions and bone quality of the adult rat mandible
Morphological and biomechanical features of the mandible are negatively affected by protein-energy malnutrition, whose effects are appa...
The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo
The specific biological function of the cell surface or membrane-bound isoform of colony-stimulating factor-1 (mCSF-1) is not well unde...
Vitamin D deficiency in guinea pigs: exacerbation of bone phenotype during pregnancy and disturbed fetal mineralization, with recovery by 1,25(OH)2D3 infusion or dietary calcium-phosphate supplementation
Vitamin D (D) deficiency during human pregnancy appears to disturb fetal growth and mineralization, but fetal development is normal in ...
Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats
Vitamin K(2) (K(2), menatetrenone) has been reported to enhance bone formation and inhibit bone resorption in vitro. However, there is ...
The role of estrogen receptor-beta, in the early age-related bone gain and later age-related bone loss in female mice
The molecular and cellular mechanism of estrogen action in skeletal tissue remains unclear. The purpose of this study was to understand...
Subclinical hypervitaminosis A causes fragile bones in rats
Excessive intake of vitamin A has been associated with an increased risk of hip fracture in humans. This finding has raised the questio...
Regional bone loss after orthotopic liver transplantation in inbred rats: the role of hepatic denervation
Bone loss and long-term persistence of osteoporosis with increased fracture risk are common after liver transplantation. It is unknown ...
Quantitative trait loci for bone density in mice: the genes determining total skeletal density and femur density show little overlap in F2 mice
Bone mineral density variation is a highly heritable trait and is the best predictor of skeletal fragility. Total skeletal density was ...