Insulin-like growth factor-binding protein-5 induces a gender-related decrease in bone mineral density in transgenic mice
IGF-binding protein-5 (IGFBP-5) is abundant in serum and bone during normal skeletal development, but levels decrease in osteoporosis. ...
Bone mineral density in male Baltic grey seal (Halichoerus grypus)
Bone mineral density (mg cm(-3)) was studied in male Baltic grey seals (4-23 years of age) by noninvasive computed tomography (pQCT). T...
Abnormal bone composition in female juvenile American alligators from a pesticide-polluted lake (Lake Apopka, Florida)
Reproductive disorders have been found in pesticide-exposed alligators living in Lake Apopka, Florida (USA). These disorders have been ...
Abnormal bone architecture and biomechanical properties with near-lifetime treatment of rats with PTH
Skeletal effects are described for near-lifetime treatment of young, female rats with recombinant human PTH (1-34) (PTH). Rats (5-8 wk ...
Local ex vivo gene therapy with bone marrow stromal cells expressing human BMP4 promotes endosteal bone formation in mice
BACKGROUND: Bone loss in osteoporosis is caused by an imbalance between resorption and formation on endosteal surfaces of trabecular an...
Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ERbeta(-/-) mice
Ovariectomy in young, growing rodents results in decreased trabecular bone mineral density (BMD) and increased radial growth of the cor...
A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis
The b and c variants of fibroblast growth factor receptor 2 (FGFR2) differ in sequence, binding specificity, and localization. Fgfr2b, ...
Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats
This study was designed to determine the effects of 28 days of hindlimb unloading (HU) on the mature female rat skeleton. In vivo proxi...
Determination of mechanical stiffness of bone by pQCT measurements: correlation with non-destructive mechanical four-point bending test data
Mechanical tests of bone provide valuable information about material and structural properties important for understanding bone patholo...
Differential skeletal responses of hindlimb unloaded rats on a vitamin D-deficient diet to 1,25-dihydroxyvitamin D3 and its analog, seocalcitol (EB1089)
Conditions of disuse in bed rest patients, as well as microgravity experienced by astronauts are accompanied by reduced mechanical load...