Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat
Current bisphosphonate therapies effectively prevent bone loss in postmenopausal women. We studied the effect of a single intravenous d...
Effect of osteoporosis on bone mineral density and fracture repair in a rat femoral fracture model
Osteoporosis (OP) is one of the most prevalent bone diseases worldwide with bone fracture the major clinical consequence. The effect of...
Cortical bone loss in androgen-deficient aged male rats is mainly caused by increased endocortical bone remodeling
INTRODUCTION: Hypogonadism is considered to be one of the major risk factors for osteoporosis in men. Here, we sequentially studied the...
Correlation among geometric, densitometric, and mechanical properties in mandible and femur of osteoporotic rats
We have previously demonstrated bone loss of the mandible and femur in experimental osteoporotic rats and its prevention by medication,...
Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats
EtOH consumption significantly impaired anabolic rebuilding of bone after lactation. Lower BMD and BMC in EtOH-fed rats were associated...
Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following 3 years of daily treatment
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated ...
Pathogenesis of age-related osteoporosis: impaired mechano-responsiveness of bone is not the culprit
BACKGROUND: According to prevailing understanding, skeletal mechano-responsiveness declines with age and this apparent failure of the m...
Combined xeno/auto-grafting of a benign osteolytic lesion in a dog, using a novel bovine cancellous bone biomaterial
CASE HISTORY: A 4-year-old female Labrador Retriever was diagnosed with an osteolytic lesion of the right distal radius. CLINICAL FINDI...
CART deficiency increases body weight but does not alter bone strength
The regulation of bone metabolism mediated by leptin is a complex process that is not clearly understood. Recent studies suggest that C...
Effect of preoperative combined treatment with alendronate and calcitriol on fixation of hydroxyapatite-coated implants in ovariectomized rats
BACKGROUND:
Osteoporosis is a potential risk factor affecting implant stability following total joint arthroplasty. Bisphosphonates ar...