{"id":166702,"date":"2025-01-20T16:38:13","date_gmt":"2025-01-20T15:38:13","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/sarcopenia-in-long-term-survivors-of-cancer-in-childhood-and-adolescence-a-cross-sectional-study-of-calf-muscle-mass-by-peripheral-quantitative-computed-tomography-with-an-examination-of-the-muscle-2\/"},"modified":"2025-01-20T16:38:14","modified_gmt":"2025-01-20T15:38:14","slug":"sarcopenia-in-long-term-survivors-of-cancer-in-childhood-and-adolescence-a-cross-sectional-study-of-calf-muscle-mass-by-peripheral-quantitative-computed-tomography-with-an-examination-of-the-muscle-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/sarcopenia-in-long-term-survivors-of-cancer-in-childhood-and-adolescence-a-cross-sectional-study-of-calf-muscle-mass-by-peripheral-quantitative-computed-tomography-with-an-examination-of-the-muscle-2\/","title":{"rendered":"Sarcopenia in long-term survivors of cancer in childhood and adolescence: A  cross-sectional study of calf muscle mass by peripheral quantitative computed  tomography with an examination of the muscle-bone unit."},"content":{"rendered":"<p>BACKGROUND: Sarcopenia, a loss of systemic skeletal muscle mass (SMM), is  prevalent in childhood cancer survivors and often accompanied by increased fat  mass (sarcopenic obesity [SO]). We examined whether calf muscle cross-sectional  area (CSA), measured by peripheral quantitative computed tomography (pQCT), can  identify sarcopenia and SO in long-term survivors of pediatric acute  lymphoblastic leukemia (ALL), and explored its relationship with adjacent bone  geometry. PROCEDURES: Calf muscle CSA and CSA Z scores at the 38% tibia in 70  subjects (median survival 15 years) were compared between sexes and ALL risk  group, and their association with sarcopenia and SO evaluated. Relationships  between bone strength and muscle mass were assessed further using linear  regression and methods described by Schoenau et al. for evaluation of a  functional muscle-bone unit. RESULTS: A calf muscle CSA Z score of less than or  equal to zero is 73.81% sensitive and 84.62% specific for detecting sarcopenia  defined by height-adjusted appendicular lean mass measured by dual-energy x-ray  absorptiometry. No significant difference in CSA Z scores was noted between sexes  or ALL risk groups; however, Z scores were markedly higher in those without SO  (adjusted odds ratio 0.529, 95% confidence interval [CI]: 0.340-0.824). Ratios of  calf muscle mass to height and total bone mineral content at the 38% tibia are  &#8216;sufficient&#8217; and consistent with estimated reference ranges for a healthy  population. CONCLUSIONS: CSA Z scores may represent a useful clinical measure of  SMM and are predictive of SO in this population. Our results are supportive of a  functional muscle-bone unit in long-term survivors of pediatric ALL.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BACKGROUND: Sarcopenia, a loss of systemic skeletal muscle mass (SMM), is prevalent in childhood cancer survivors and often accompanied by<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5944,5924,5866,5862],"produktgruppe":[5825],"literatur_kategorie":[7213],"class_list":["post-166702","literatur","type-literatur","status-publish","format-standard","hentry","thema-clinical-application-en","thema-clinical-studies","thema-diagnostics-using-leonardo-pqct","thema-pqct-en","produktgruppe-pqct-en","literatur_kategorie-scientific-publications"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/166702","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/166702\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=166702"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=166702"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=166702"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=166702"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=166702"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}