{"id":166600,"date":"2025-01-20T16:35:00","date_gmt":"2025-01-20T15:35:00","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/development-of-musculoskeletal-deficits-in-children-with-cystic-fibrosis-in-later-childhood-2\/"},"modified":"2025-01-20T16:35:01","modified_gmt":"2025-01-20T15:35:01","slug":"development-of-musculoskeletal-deficits-in-children-with-cystic-fibrosis-in-later-childhood-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/development-of-musculoskeletal-deficits-in-children-with-cystic-fibrosis-in-later-childhood-2\/","title":{"rendered":"Development of musculoskeletal deficits in children with cystic fibrosis in later  childhood."},"content":{"rendered":"<p>Cystic fibrosis (CF) is a genetic condition primarily affecting the respiratory  system, with the associated progressive lung damage and loss of function  resulting in reduced lifespan. Bone health is also impaired in individuals with  CF, leading to much higher fracture risk even in adolescence. However, the  development of these deficits during growth and the relative contributions of  puberty, body size and muscular loading remain somewhat unexplored. We therefore  recruited 25 children with CF (10 girls, mean age 11.3\u00e2\u20ac\u00af+\/-\u00e2\u20ac\u00af2.9y) and 147 children  without CF (75 girls, mean age 12.4\u00e2\u20ac\u00af+\/-\u00e2\u20ac\u00af2.6y). Bone characteristics were assessed  using peripheral quantitative computed tomography (pQCT) at 4\u00e2\u20ac\u00af% and 66\u00e2\u20ac\u00af%  distal-proximal tibia. Muscle cross-sectional area (CSA) and density (an  indicator of muscle quality) were also assessed at the latter site. Tibial bone  microstructure was assessed using high-resolution pQCT (HR-pQCT) at 8\u00e2\u20ac\u00af%  distal-proximal tibial length. In addition, peak jump power and hop force were  measured using jumping mechanography. Group-by-age interactions and group  differences in bone and muscle characteristics were examined using multiple  linear regression, adjusted for age, sex and pubertal status and in additional  models, height and muscle force. In initial models group-by-age interactions were  evident for distal tibial total bone mineral content (BMC) and trabecular  volumetric bone mineral density (vBMD), with a lower rate of age-related accrual  evident in children with CF. In assessments of distal tibial microstructure,  similar patterns were observed for trabecular number and thickness, and cortical  CSA. In the tibial shaft, group-by-age interactions indicating slower growth in  CF were evident for total BMC and cortical CSA, whilst age-independent deficits  in CF were observed for several other variables. Peak jump power and hop force  also exhibited similar interactions. Group-by-age interactions for bone were  partially attenuated at the distal tibia and fully attenuated at the tibial shaft  by adjustment for muscle force. These results suggest that bone and muscle  deficits in children with CF develop throughout later childhood, independent of  differences in pubertal stage and body size. These diverging growth patterns  appear to be mediated by differences in muscle function, particularly for bone  characteristics in the tibial shaft. Given high fracture risk in this population  from childhood onwards, development of interventions to improve bone health would  be of substantial clinical value.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Cystic fibrosis (CF) is a genetic condition primarily affecting the respiratory system, with the associated progressive lung damage and loss<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5924,5866,5860,5936],"produktgruppe":[5827,5825],"literatur_kategorie":[7221],"class_list":["post-166600","literatur","type-literatur","status-publish","format-standard","hentry","thema-clinical-studies","thema-diagnostics-using-leonardo-pqct","thema-leonardo-mechanography-en","thema-medical-application","produktgruppe-leonardo-en","produktgruppe-pqct-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/166600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/166600\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=166600"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=166600"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=166600"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=166600"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=166600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}