{"id":165878,"date":"2025-01-20T16:10:35","date_gmt":"2025-01-20T15:10:35","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/combination-of-dxa-and-bis-body-composition-measurements-is-highly-correlated-with-physical-function-an-approach-to-improve-muscle-mass-assessment-2\/"},"modified":"2025-01-20T16:10:36","modified_gmt":"2025-01-20T15:10:36","slug":"combination-of-dxa-and-bis-body-composition-measurements-is-highly-correlated-with-physical-function-an-approach-to-improve-muscle-mass-assessment-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/combination-of-dxa-and-bis-body-composition-measurements-is-highly-correlated-with-physical-function-an-approach-to-improve-muscle-mass-assessment-2\/","title":{"rendered":"Combination of DXA and BIS body composition measurements is highly correlated with physical function-an approach to improve muscle mass assessment."},"content":{"rendered":"<p>RATIONALE: Fluid volume estimates may help predict functional status and thereby  improve sarcopenia diagnosis. MAIN RESULT: Bioimpedance-derived fluid volume, combined with DXA, improves identification of jump power over traditional measures. SIGNIFICANCE: DXA-measured lean mass should be corrected for fluid distribution in older populations; this may be a surrogate of muscle quality. PURPOSE: Sarcopenia, the age-related loss of muscle mass and function, negatively impacts functional status, quality of life, and mortality. We aimed to determine  if bioimpedance spectroscopy (BIS)-derived estimates of body water compartments can be used in conjunction with dual-energy X-ray absorptiometry (DXA) measures to aid in the prediction of functional status and thereby, ultimately, improve the diagnosis of sarcopenia. METHODS: Participants (&gt;\/= 70 years) had physical and muscle function tests, DXA, and BIS performed. Using a BMI correction method, intracellular water (ICWc), extracellular water (ECWc), and ECWc to ICWc (E\/Ic) ratio was estimated from standard BIS measures. Jump power was assessed using jump mechanography. RESULTS: The traditional measure used to diagnose sarcopenia, DXA-derived appendicular lean mass (ALM) corrected for height (ALM\/ht(2)), was the least predictive measure explaining jump power variability (r(2) = 0.31, p &lt;  0.0001). The best measure for explaining jump power was a novel variable combining DXA ALM and BIS-derived E\/Ic ratio (ALM\/(E\/Ic); r(2) = 0.70, p &lt; 0.0001). ALM\/(E\/Ic) and ICWc had the highest correlation with jump power and grip strength, specifically jump power (r = 0.84 and r = 0.80, respectively; p &lt; 0.0001). CONCLUSIONS: The creation of a novel variable (ALM\/(E\/Ic)) improved the  ability of DXA to predict jump power in an older population. ALM\/(E\/Ic) substantially outperformed traditional lean mass measures of sarcopenia and could well be an improved diagnostic approach to predict functional status. DXA-measured ALM should be corrected for fluid distribution, i.e., ALM\/(E\/Ic); this correction may be considered a surrogate of muscle quality.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>RATIONALE: Fluid volume estimates may help predict functional status and thereby improve sarcopenia diagnosis. MAIN RESULT: Bioimpedance-derived fluid volume, combined<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5866,5920],"produktgruppe":[5827],"literatur_kategorie":[7221],"class_list":["post-165878","literatur","type-literatur","status-publish","format-standard","hentry","thema-diagnostics-using-leonardo-pqct","thema-pre-clinical-research","produktgruppe-leonardo-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165878","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165878\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=165878"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=165878"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=165878"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=165878"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=165878"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}