{"id":165604,"date":"2025-01-20T15:58:31","date_gmt":"2025-01-20T14:58:31","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/supplementation-with-2000-iu-of-cholecalciferol-is-associated-with-improvement-of-trabecular-bone-mineral-density-and-muscle-power-in-pediatric-patients-with-ibd-2\/"},"modified":"2025-01-20T15:58:32","modified_gmt":"2025-01-20T14:58:32","slug":"supplementation-with-2000-iu-of-cholecalciferol-is-associated-with-improvement-of-trabecular-bone-mineral-density-and-muscle-power-in-pediatric-patients-with-ibd-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/supplementation-with-2000-iu-of-cholecalciferol-is-associated-with-improvement-of-trabecular-bone-mineral-density-and-muscle-power-in-pediatric-patients-with-ibd-2\/","title":{"rendered":"Supplementation with 2000 IU of Cholecalciferol Is Associated with Improvement of Trabecular Bone Mineral Density and Muscle Power in Pediatric Patients with IBD."},"content":{"rendered":"<p>BACKGROUND: Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is frequently found in IBD; however, the effect of vitamin D supplementation on bone health of children with IBD is poorly understood. We aimed to observe the changes in volumetric bone density and dynamic muscle functions after vitamin D substitution in a cohort of pediatric patients with IBD. METHODS: This was a prospective observational study of 55 patients (aged 5-19 years) with IBD. Bone quality was assessed using peripheral quantitative computed tomography and muscle functions by jumping mechanography at baseline and after a median of 13.8 (interquartile range, 12.0-16.0) months of daily substitution of 2000 IU of cholecalciferol. RESULTS: Median serum levels of 25-hydroxyvitamin D increased from 58 nmol\/L at the baseline visit to 85 nmol\/L at the last follow-up visit (P &lt; 0.001); no signs of overdose were reported. The Z-scores of trabecular bone mineral density, cortical bone cross-sectional area, and maximal muscle power improved significantly during the follow-up period (+0.5, P = 0.001, +0.3, P = 0.002 and +0.5, P = 0.002, respectively). Cholecalciferol substitution was positively associated with trabecular bone mineral density and maximal muscle power (estimates 0.26, 95% confidence interval 0.14-0.37, P &lt; 0.0001 and 0.60, 95% confidence interval 0.32-0.85, P &lt; 0.0001, respectively) but not with the Strength-Strain Index or maximal muscle force (Fmax). CONCLUSIONS: We observed an improvement in bone and muscle parameters after cholecalciferol substitution in pediatric patients with IBD. Therefore, vitamin D substitution can be considered  in such patients.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>BACKGROUND: Inflammatory bowel diseases (IBD) are associated with altered bone health and increased risk for fractures. Vitamin D deficiency is<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[1942,1371],"thema":[5866,5878,5856],"produktgruppe":[5827,5825],"literatur_kategorie":[7221],"class_list":["post-165604","literatur","type-literatur","status-publish","format-standard","hentry","tag-leonardo-mechanograpy","tag-pqct","thema-diagnostics-using-leonardo-pqct","thema-medical-applications","thema-therapy-prevention-using-galileo","produktgruppe-leonardo-en","produktgruppe-pqct-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165604","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165604\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=165604"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=165604"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=165604"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=165604"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=165604"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}