CONTEXT: Areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is used clinically to predict fracture but does not allow discrimination between the trabecular and cortical bone compartments or assessment of cortical porosity. OBJECTIVE: To investigate if distinct information on cortical and trabecular bone parameters predict fracture risk independently of aBMD and clinical risk factors. DESIGN & PARTICIPANTS: Cortical area, cortical bone mass, trabecular bone volume fraction, and cortical porosity were measured at the tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT) in 456 men (80.2+\/-3.5 years) recruited from the general population in Gothenburg, Sweden. aBMD was measured using DXA. Incident fractures (71 men with fracture) were X-ray verified. The associations with incident fracture were evaluated using Cox proportional hazard models. RESULTS: In models adjusted for age and BMI, cortical area (HR per SD decrease, 2.05; 95% CI, 1.58-2.65), cortical bone mass (HR per SD decrease, 2.07; 95% CI, 1.58-2.70), and trabecular BV\/TV (HR, 1.62; 1.26-2.07) but not cortical porosity, were independently associated with fracture risk. These association remained essentially unaffected after adjustment for femoral neck aBMD and FRAX risk factors (area: HR 1.96 (1.44-2.66); cortical bone mass: HR 1.99 (1.45-2.74); trabecular BV\/TV: HR 1.46 (1.09-1.96)). In all adjusted models, inclusion of both BV\/TV and cortical area or cortical bone mass entered simultantously, only the cortical parameters remained significant predictors of fracture. CONCLUSION: We propose that HR-pQCT measurment of cortical area or cortical bone mass might add clinically useful information for the evaluation of fracture risk.<\/p>\n","protected":false},"excerpt":{"rendered":"
CONTEXT: Areal bone mineral density (aBMD) measured using dual-energy X-ray absorptiometry (DXA) is used clinically to predict fracture but does<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5924,5866,5868,5856],"produktgruppe":[5825],"literatur_kategorie":[7221],"class_list":["post-165380","literatur","type-literatur","status-publish","format-standard","hentry","thema-clinical-studies","thema-diagnostics-using-leonardo-pqct","thema-over-all-concept","thema-therapy-prevention-using-galileo","produktgruppe-pqct-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165380\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=165380"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=165380"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=165380"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=165380"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=165380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}