Background: Vascular dysfunction due to hyperglycemia in individuals with diabetes is a
\nfactor contributing to distal symmetric polyneuropathy (DSP). Reactive oxygen species (ROS)
\nreduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced
\ncirculation and nerve ischemia. Increases in blood NO concentrations and circulation have been
\nattributed to whole body vibration (WBV). The purpose of this study was to the determine the
\neffects of low frequency, low amplitude WBV on whole blood NO concentration and skin blood
\nflow (SBF) in individuals with symptoms of DSP.
\nResearch Design and Methods: Ten subjects with diabetes and impaired sensory
\nperception in the lower limbs participated in this cross-over study. Each submitted to two
\ntreatment conditions, WBV and sham, with a one week washout period between. Blood draws
\nfor NO analysis and Doppler laser image scans of SBF were performed before, immediately after
\nand following a 5 minute recovery of each the treatments.
\nResults: Low frequency, low amplitude WBV vibration significantly increased skin blood
\nflow compared to the sham condition (F2,18=5.82, p=0.0115). Whole blood nitric oxide
\nconcentrations did not differ between the WBV and sham condition immediately or 5 minutes
\npost-treatment (F2,18=1.88, p=0.1813)
\nConclusions: These findings demonstrate that subjects with diabetes respond to whole
\nbody vibration with increased skin blood flow compared to sham condition. The implication is
\nthat WBV is a potential non-pharmacological therapy for neurovascular complications of
\ndiabetes.<\/p>\n","protected":false},"excerpt":{"rendered":"
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