This comparative study of peripheral (p) QCT, high-resolution pQCT (hr-pQCT) and 1.0
\nTesla pMRI technologies focused on quantifying short-term test-retest reproducibility,
\nvalidity, one-year detection limit and clinical sensitivity of each modality\u2019s derived bone
\nmeasures. Select bone outcomes were evaluated from scans performed on Hamiltonian
\nwomen above 50 years old and then externally validated in a population-based cohort of
\nCanadian women 60-85 years old. In the local cohort (age: 74 \u00b1 9 years and BMI 27.65 \u00b1
\n5.74 kg\/m2), Tb.Sp measured on pMRI, Ct.Th and vBMD from pQCT showed significant
\ncorrelations (r2=0.52-0.85) with hr-pQCT and yielded slopes near unity. Bland-Altman
\nanalyses revealed significant relations between magnitude of pQCT and pMRI bone
\noutcomes (Tb.Th(-), Tb.N(+), BV\/TV(-)) and level of agreement with hr-pQCT. Except
\nfor hole geometry and connectivity, short-term reproducibility was < 5% for pQCT but\nonly BV\/TV was < 5% for pMRI. The more distal slice of pQCT scans at both sites\nshowed superior reproducibility but slightly larger change than the proximal. Coregistering\nrepeat images and excluding those on antiresorptive therapy mildly reduced\nprecision error and one-year change. In the local cohort, only Ct.Th and cortical vBMD\nassociated with fragility fractures (OR: 1.09-3.28) using hr-pQCT, which was externally\nvalidated in the national cohort. Certain trabecular measures on pMRI and pQCT erred\ntowards increased odds for fractures locally. For pQCT, these became significant in the\nnational cohort (OR:1.04-3.81). The national reference dataset for hr-pQCT showed\nlarger Tb.Sp and smaller Tb.N compared to Americans but age-related rates of decline in\nCt.Th and BV\/TV were larger in Europeans. This study demonstrated validity of pMRI\nand pQCT image-derived volumetric bone outcomes and a reasonable degree of shortand\nlong-term precision error for measures derived from pQCT images but not from 1.0T\npMRI. For pMRI, a shorter scan was suggested to limit motion and to reduce precision\nerror. Performing scans more distally was recommended, but a single CT slice from\npQCT was comparable to 110 slices from hr-pQCT in associations with fractures.\n<\/p>\n","protected":false},"excerpt":{"rendered":"
This comparative study of peripheral (p) QCT, high-resolution pQCT (hr-pQCT) and 1.0 Tesla pMRI technologies focused on quantifying short-term test-retest<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[1672],"thema":[5870,5922,5924,5866,5888,5878,5920,5856,5872],"produktgruppe":[5825],"literatur_kategorie":[7221],"class_list":["post-165030","literatur","type-literatur","status-publish","format-standard","hentry","tag-morphometric-parameters-pqct-vs-hr-pqct","thema-basics","thema-clinical-application","thema-clinical-studies","thema-diagnostics-using-leonardo-pqct","thema-geriatrics","thema-medical-applications","thema-pre-clinical-research","thema-therapy-prevention-using-galileo","thema-training-education","produktgruppe-pqct-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/165030\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=165030"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=165030"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=165030"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=165030"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=165030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}