{"id":164912,"date":"2025-01-20T15:31:47","date_gmt":"2025-01-20T14:31:47","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/atypical-fast-serca1a-protein-expression-in-slow-myofibers-and-differential-s-nitrosylation-prevented-by-exercise-during-long-term-bed-rest-2\/"},"modified":"2025-01-20T15:31:48","modified_gmt":"2025-01-20T14:31:48","slug":"atypical-fast-serca1a-protein-expression-in-slow-myofibers-and-differential-s-nitrosylation-prevented-by-exercise-during-long-term-bed-rest-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/atypical-fast-serca1a-protein-expression-in-slow-myofibers-and-differential-s-nitrosylation-prevented-by-exercise-during-long-term-bed-rest-2\/","title":{"rendered":"Atypical fast SERCA1a protein expression in slow myofibers and differential S-nitrosylation prevented by exercise during long term bed rest."},"content":{"rendered":"<p>We monitored changes in SERCA isoform specific expression and S-nitrosylation in  myofibers of lower limb soleus (SOL) and vastus lateralis (VL) muscle biopsies before and after 60 days of voluntary long term bed rest (BR) without (BR-CTRL group, n = 8) and with exercise countermeasure (BR-EX group, n = 8). Before BR, a typical myofiber type-specific distribution of fast and slow SERCA1\/2a isoforms was seen. After BR, a subpopulation (approx. 15%) of slow myofibers in BR-CTRL additionally expressed the fast SERCA1a isoform which was not seen in BR-EX. After BR, SERCA1a S-nitrosylation patterns analyzed by the biotin-switch assay decreased in disused SOL only but increased in both muscles following exercise. Differential SERCA1a S-nitrosylation and SERCA1a\/2a co-expression in subsets of slow myofibers should be considered as signs of an altered cytosolic Ca(2+) homeostasis following chronic muscle disuse. Exercise preserved myofiber type-specific SERCA1a expression and S-nitrosylation in VL and SOL in a different way, suggesting muscle-specific responses to the countermeasure protocol applied  during bed rest.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>We monitored changes in SERCA isoform specific expression and S-nitrosylation in myofibers of lower limb soleus (SOL) and vastus lateralis<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[1533],"thema":[5870,5866,5868],"produktgruppe":[7527,5831,5829],"literatur_kategorie":[7221],"class_list":["post-164912","literatur","type-literatur","status-publish","format-standard","hentry","tag-bbr1","thema-basics","thema-diagnostics-using-leonardo-pqct","thema-over-all-concept","produktgruppe-galileo-en","produktgruppe-galileo-therapy","produktgruppe-galileo-training-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/164912","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/164912\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=164912"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=164912"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=164912"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=164912"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=164912"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}