{"id":164166,"date":"2025-01-20T15:18:05","date_gmt":"2025-01-20T14:18:05","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/tibial-geometry-in-individuals-with-neurofibromatosis-type-1-without-anterolateral-bowing-of-the-lower-leg-using-peripheral-quantitative-computed-tomography-2\/"},"modified":"2025-01-20T15:18:06","modified_gmt":"2025-01-20T14:18:06","slug":"tibial-geometry-in-individuals-with-neurofibromatosis-type-1-without-anterolateral-bowing-of-the-lower-leg-using-peripheral-quantitative-computed-tomography-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/tibial-geometry-in-individuals-with-neurofibromatosis-type-1-without-anterolateral-bowing-of-the-lower-leg-using-peripheral-quantitative-computed-tomography-2\/","title":{"rendered":"Tibial geometry in individuals with neurofibromatosis type 1 without anterolateral bowing of the lower leg using peripheral quantitative computed tomography."},"content":{"rendered":"<p>INTRODUCTION: Lower leg bowing with tibial pseudarthrosis is associated with neurofibromatosis type 1 (NF1). The objective of the study is to determine if the geometry of the lower limb in individuals with neurofibromatosis type 1 (NF1) differs from controls, and to characterize the osseous components of the tibia in NF1. METHODS: Peripheral quantitative computed tomography (pQCT) of the lower limb was performed (90 individuals with NF1 without tibial and\/or fibular dysplasia: 474 healthy individuals without NF1). Subjects were 4-18 years of age. Individuals with NF1 were compared to controls using an analysis-of-covariance with a fixed set of covariates (age, weight, height, Tanner stage, and gender). RESULTS: Using pQCT, NF1 individuals without bowing of the lower leg have smaller periosteal circumferences (p&lt;0.0001), smaller cortical area (p&lt;0.0001), and decreased tibial cortical and trabecular bone mineral content (BMC) (p&lt;0.0001) compared to controls. DISCUSSION: Individuals with NF1 have a different geometry  of the lower leg compared to healthy controls suggesting that NF1 haploinsufficiency impacts bone homeostasis although not resulting in overt anterolateral bowing of the lower leg.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>INTRODUCTION: Lower leg bowing with tibial pseudarthrosis is associated with neurofibromatosis type 1 (NF1). The objective of the study is<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5922,5924,5866],"produktgruppe":[5825],"literatur_kategorie":[7221],"class_list":["post-164166","literatur","type-literatur","status-publish","format-standard","hentry","thema-clinical-application","thema-clinical-studies","thema-diagnostics-using-leonardo-pqct","produktgruppe-pqct-en","literatur_kategorie-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/164166","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/164166\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=164166"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=164166"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=164166"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=164166"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=164166"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}