{"id":162976,"date":"2025-01-20T14:28:30","date_gmt":"2025-01-20T13:28:30","guid":{"rendered":"https:\/\/stratec-med.com\/literatur\/mouse-genetic-model-for-bone-strength-and-size-phenotypes-nzb-b1nj-and-rf-j-inbred-strains-2\/"},"modified":"2025-01-20T14:28:31","modified_gmt":"2025-01-20T13:28:31","slug":"mouse-genetic-model-for-bone-strength-and-size-phenotypes-nzb-b1nj-and-rf-j-inbred-strains-2","status":"publish","type":"literatur","link":"https:\/\/stratec-med.com\/en\/literature\/mouse-genetic-model-for-bone-strength-and-size-phenotypes-nzb-b1nj-and-rf-j-inbred-strains-2\/","title":{"rendered":"Mouse genetic model for bone strength and size phenotypes: NZB\/B1NJ and RF\/J inbred strains"},"content":{"rendered":"<p>The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB\/B1NJ and RF\/J. Measurement of the femur midshaft size by peripheral quantitative computed tomography (pQCT) showed that the RF\/J mice had a 32% greater cross-sectional area than NZB\/B1NJ mice at 10 weeks of age, and a 38% greater cross-sectional area at 22 weeks of age. Body weight in the RF\/J mice was 10% higher at 10 weeks but 9% lower at 22 weeks. Bone strength was determined by a three-point bending method. In agreement with the difference in bone cross-sectional area, the femurs of the RF\/J mice were stronger (80% greater) and stiffer (80% greater) than the bones of the NZB\/B1NJ mice. To determine whether periosteal bone formation played a role in the greater size of the RF\/J mice, the mice were injected with tetracycline to label areas of new bone formation. Histomorphometrical analysis of the femur diaphysis demonstrated higher rates of periosteal bone formation (131% greater) and of periosteal forming surface (81% greater) in RF\/J than in NZB\/B1NJ mice. We conclude that a high rate of periosteal bone formation increases bone size and strength in RF\/J mice when compared with NZB\/B1NJ mice. The NZB\/B1NJ and RF\/J mice should be an excellent model to investigate the genes that regulate femur size and strength. Copyright 2002 by Elsevier Science Inc.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The relationships of bone size, bone strength, and bone formation were investigated in two strains of mice, NZB\/B1NJ and RF\/J.<\/p>\n","protected":false},"author":22,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false},"tags":[],"thema":[5866,5920],"produktgruppe":[5825],"literatur_kategorie":[7223],"class_list":["post-162976","literatur","type-literatur","status-publish","format-standard","hentry","thema-diagnostics-using-leonardo-pqct","thema-pre-clinical-research","produktgruppe-pqct-en","literatur_kategorie-pre-clinical-studies"],"acf":[],"_links":{"self":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/162976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur"}],"about":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/types\/literatur"}],"author":[{"embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/users\/22"}],"version-history":[{"count":0,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur\/162976\/revisions"}],"wp:attachment":[{"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/media?parent=162976"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/tags?post=162976"},{"taxonomy":"thema","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/thema?post=162976"},{"taxonomy":"produktgruppe","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/produktgruppe?post=162976"},{"taxonomy":"literatur_kategorie","embeddable":true,"href":"https:\/\/stratec-med.com\/en\/wp-json\/wp\/v2\/literatur_kategorie?post=162976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}