We have hypothesized that some vegetables which are part of the regular human diet may contain modulators of bone metabolism. To mimic a typical Western diet with large proportions of refined components, rats were pair-fed a semi-purified diet to which, in the treated animals, the dried material under investigation was added. Effects are expressed as % of untreated control. Bone parameters in rats were assessed in the proximal tibia by pQCT. Bone resorption (BR) was assessed by the urinary excretion of [3H]-tetracycline from prelabeled rats. Daily administration of 1 g of onion during 4 weeks increased total bone mineral content by 17.4% (p<0.05), trabecular bone mineral density by 13.6% (p<0.05). One g of onion\/day administered to male rats blunted BR by 23-\/+5% (p<0.05). Daily administration of onion to ovariectomized rats inhibited BR in a dose-dependent manner. At the highest dose (1.5 g of onion) BR was inhibited by 26-\/+4% (p<0.01) as compared to 24-\/+3% (p<0.001) for estradiol (27microg\/kg\/day). An additional 13 vegetables displayed significant effects on BR at the dose of 1g\/day. Interestingly, 1g\/day of soy did not inhibit BR in this model. Also, skimmed milk, meat and egg (all 1 g\/day) were ineffective. Thus, common vegetables consumed by humans potently modulate bone metabolism in the rat. This opens the possibility to develop the basis for a low-cost, safe and effective nutritional approach to osteoporosis.\n<\/p>\n","protected":false},"excerpt":{"rendered":"
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